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科研服务
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地 址:武汉市东湖新技术开发区高新大道666号,武汉
国家生物产业基地B、C、D区研发楼C1栋
产品销售:15926423062
技术服务:18971263062
E - mail :info@hylpnm.com
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产品名称:
Research Grade Adalimumab ( 阿达木单抗 )
NO.
002
货号:
CSD00093
中文名称
阿达木单抗
英文名词
Research Grade Adalimumab
CAS号
331731-18-1
产品货号:
CSD00093
货期:
现货
价格与订购:
2480.00
数量:
-
+
库存:
100
产品信息
如何订购
货号(Catalog No.)icon
CSD00093
通用名INNicon
Adalimumab
纯度(Purity)icon
>95%
浓度( Concentration)icon
1mg/ml
Formulationicon
PBS buffer PH7.5
Sourceicon
CHO cells
内毒素(Endotoxin level)icon
Please contact with the lab for this information.
产品描述(Description)icon
Adalimumab is a subcutaneously administered biological disease modifier for the treatment of rheumatoid arthritis and other chronic debilitating diseases mediated by tumor necrosis factor 2, 3. It was originally launched by Abbvie in the U.S. and approved in 2002 by the FDA 1. This drug is frequently known as Humira. It is produced by recombinant DNA technology using a mammalian cell expression system. This drug is available in a prefilled syringe form and convenient pen form for subcutaneous self-administered doses 1. A new biosesimilar to adalimumab, named adalimumab-adaz, was approved by the FDA on October 31, 2018. This biosesimilar is known as Hyrimoz, and is a trademark of Novartis AG 9.
别名(Alternative names)icon
D2E7
靶点;物种(Specificity target name;species)icon
TNFSF2/TNF-alpha/TNFA[Homo sapiens]
活性研究(体外/体内研究)(Activity in vitro)icon
Adalimumab (anti-TNF-alpha) blocks the interaction of TNF with the p55 and p75 cell surface TNF receptors, thereby neutralising the activity of this cytokine. Through its anti-TNF actions, adalimumab reduces concentrations of matrix metalloproteases (MMP-1 and -3) and other markers of cartilage and synovium turnover, reduces of matrix metalloproteases (MMP-1 and -3) and other markers of cartilage and synovium turnover, and reduces concentrations of acute phase reactants of inflammation (C-reactive protein [CRP] and erythrocyte sedimentation rate [ESR]) and serum cytokines (IL-1β mRNA, IL-1 receptor antagonist, IL-6).
种类(Species)icon
Homo sapiens
受体鉴定(Receptor identification)icon
IgG1-kappa
分子量(MV)icon
148000.00 Da
CASicon
331731-18-1
存储条件(Storage)icon
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
Noteicon
For research use only .
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