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科研服务
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地 址:武汉市东湖新技术开发区高新大道666号,武汉
国家生物产业基地B、C、D区研发楼C1栋
产品销售:15926423062
技术服务:18971263062
E - mail :info@hylpnm.com
邮 编:430075
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产品名称:
Research Grade Nivolumab ( 纳武单抗 )
NO.
010
货号:
CSD00292
中文名称
纳武单抗
英文名词
Research Grade Nivolumab
CAS号
946414-94-4
产品货号:
CSD00292
货期:
现货
价格与订购:
2480.00
数量:
-
+
库存:
10
产品信息
如何订购
货号(Catalog No.)icon
CSD00292
通用名INNicon
Nivolumab
纯度(Purity)icon
>95%
浓度( Concentration)icon
1mg/ml
Formulationicon
PBS buffer PH7.5
Sourceicon
CHO cells
内毒素(Endotoxin level)icon
Please contact with the lab for this information.
产品描述(Description)icon
Nivolumab is a programmed death receptor-1 (PD-1) blocking antibody to treat advanced (metastatic) non-small cell lung cancer.
别名(Alternative names)icon
BMS-936558,MDX-1106,ONO-4538
靶点;物种(Specificity target name;species)icon
PDCD1/PD1/CD279[Homo sapiens]
活性研究(体外/体内研究)(Activity in vitro)icon
Nivolumab binds to CHO cells expressing PD-1 with an EC50 of 1.66 nM, but does not bind to the parental CHO cell line. Nivolumab binds to PD-1 on activated T cells with an EC50 of 0.64 nM. Nivolumab also inhibits the interaction between PD-1 and its ligands, PD-L1 and PD-L2, with IC50 values of 2.52 and 2.59 nM, respectively. Nivolumab (1.5 ng/mL) can enhance T-cell reactivity in the presence of a T-cell receptor stimulus.
种类(Species)icon
Homo sapiens
受体鉴定(Receptor identification)icon
IgG4-kappa
分子量(MV)icon
143599.09 Da
CASicon
946414-94-4
存储条件(Storage)icon
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
Noteicon
For research use only .
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